moe. is celebrating Halloween on Saturday, October 27th, at The Fillmore Philadelphia with a special video game-themed “night at the arcade.” For fans that can’t make it, the band is offering a live stream via nugs.tv, available in SD and HD webcasts here.In order to get fans in the gamer spirit for Halloween, the band recently launched Buster Brawl, an NES-style 8-bit video game in which the user plays the titular flying pig from the band’s “Buster”. The band encourages fans to “Grab your Mountain Dew and mozzarella, get that perfect amount of grease on the joystick, test your skills at Buster Brawl to make sure you are properly ready for Vintage Video Game Night right here on the .org!!!” Try your hand at “Buster Brawl” on the band’s website now.While moe. was forced to take last Halloween off as bassist Rob Derhak received treatment for cancer, moe. has celebrated Quentin Tarantino films (2016), Star Wars movies (2015), The Big Lebowski (2014), and more in the past. This year’s video game theme should make for another special All Hallows Eve with moe.!For a full list of moe.’s upcoming tour dates, head to the band’s website.
Harvard Law School (HLS) Professor Jonathan Zittrain ’95, a leading scholar on the legal and policy issues surrounding the Internet, has been appointed to the faculty of the Harvard School of Engineering and Applied Sciences (SEAS) as professor of computer science. Zittrain is a co-founder of the University’s Berkman Center for Internet & Society.“Jonathan’s appointment is a critical step in fostering stronger ties between HLS and SEAS,” said SEAS Dean Cherry A. Murray, the John A. and Elizabeth S. Armstrong Professor of Engineering and Applied Sciences and professor of physics. “Given the complexities of issues such as the security and privacy of data and medical records, open access scholarship, and the changing nature of digital identities — from social networks to gaming avatars — understanding the connections between law and technology is increasingly important. We believe that by leveraging the strengths of both our Schools, Harvard will become a leading player in this exciting interface.”The author of “The Future of the Internet — And How to Stop It,” Zittrain’s scholarly work bridges theory and experiment, prototyping tools for and on the Internet. His concept of the shifting roles of public and private institutions is the intellectual underpinning for StopBadware, a large-scale empirical study of the flow of Internet malware online.“I am delighted that through Jonathan’s work, we are able to foster strengthened ties to the Engineering School,” said HLS Dean Martha Minow. “Jonathan’s work has long drawn upon his background in computer science, and his groundbreaking analysis combines legal, political, and technological analyses in helping to shape and reassess the quickly changing field of cyberlaw. His new appointment to SEAS strengthens his work, offers new opportunities for collaborations between our Schools, and deepens Harvard’s commitments to creative and comprehensive thinking about the challenges and opportunities of this digital age.”To read the full story.
Read Full Story A newly discovered cellular messaging mechanism could lead to a new way to deliver therapeutics to tissues affected by disease, according to a new study from Harvard T.H. Chan School of Public Health. Researchers found that a type of extracellular vesicle (EV) — a sac secreted by cells that contains proteins and RNA molecules — known as ARMMs also carries receptors that allow signaling without direct contact between cells. This capability may make ARMMs uniquely suited to be engineered to send therapeutics directly to affected areas of the body.“EVs are like messages in a bottle between cells,” said senior author Quan Lu, associate professor of environmental genetics and pathophysiology. “We think that within the next few years, we may be able to swap the endogenous molecules in ARMMs for therapeutic cargos — such as antibodies — and to engineer ARMMs to home in on a particular tissue.”The study was published online Sept. 27, 2017 in Nature Communications.There are an estimated 37 trillion cells in the human body — and 100 times that many EVs. They circulate in the blood and other bodily fluids and are involved in processes such as coagulation and the immune response. They can also be hijacked to spread cancer or viruses like HIV and Ebola.EVs are generating a great deal of interest in the biotechnology field. Researchers believe that the molecules they carry include the fingerprints of disease and harmful environmental exposures. Work is already underway on developing a “liquid biopsy” to test EVs in a drop of blood.Previous work by Lu’s lab described the body’s mechanism for producing ARMMs. Unlike other EVs, which are generated within cells, ARMMs are secreted directly from the plasma membrane at the cell’s surface. Although the physiological function of ARMMs remains unknown, the way that they are made may make them uniquely suited to carry certain molecules.In the current study, the researchers found that ARMMs contain molecules used for NOTCH signaling, a type of intercellular communication that normally requires cell-to-cell contact. NOTCH receptors are plasma membrane proteins involved in critical physiological roles such as embryonic development, tissue homeostasis, and stem cell function. According to the new findings, ARMMs are able to facilitate NOTCH receptor signaling at a distance.“Our research on ARMMs has tremendous potential for therapeutics and public health,” Lu said. While other researchers have explored using EVs to deliver therapeutics, directing them within the body has been an obstacle. Lu believes that ARMMs provide a way past that barrier, and he was recently awarded a patent for generating, isolating, and engineering ARMMs. “It will likely be at least 10 years before we see these methods used in a clinical setting,” Lu said. “But the path forward is clear.” The study’s first author was Qiyu Wang, a research associate at Harvard Chan School.This study was supported in part by a National Institutes of Health R01grant (R01 HL114769) and by funding from the Blavatnik Biomedical Accelerator Fund.
Richard A. Smith, a former member of both of Harvard’s governing boards, has died at age 95. Smith was a member of the Harvard Corporation from 1991 to 2000, and an Overseer from 1989 to 1991. A prominent philanthropist, executive, nonprofit trustee, and Harvard citizen, he and his wife, Susan, provided a transformative gift to the University for the redesign and renovation of what was formerly Holyoke Center, and the Richard A. and Susan F. Smith Campus Center opened in 2018.Smith was also a member of the governing boards’ Joint Committee on Appointments for eight years, sat on the executive committee of the Committee on University Resources, and was a member of several visiting committees. In addition, he served on the board of the Harvard Management Company, which manages the University’s endowment.“Dick Smith loved Harvard,” recalled Harvard President Larry Bacow, “and he always looked on the institution with a critical eye — wondering how it could and should be improved for the people who would care for it after him. The University we know today would not be the same without his efforts and his generosity. Together with his wife Susan, Dick created for all of us a campus center that has truly become the heart of our community, a gathering place that celebrates the best of what we can be when we are together — creative, energized, and optimistic. He will be greatly missed and fondly remembered.”He was a member of the College Class of 1946 and had enlisted in the Navy during World War II. He was awarded an honorary degree from Harvard in 2001, cited for “[h]is incisive mind, his concern for the fundamental values and purposes of Harvard, his great experience, and his eye for what is really significant in a given situation.” His honorary-degree citation recognized him as a “superlative and civic-minded executive, whose insight and dedication have invigorated medical research and advanced the enterprise of education.”An engaged and devoted alumnus, Smith was chair of the Class of 1946, chair of his 50th and 55th Reunion Gift Steering Committees, and a member of the Harvard College Fund Council.Richard A. Smith (center) with President Larry Bacow and President Emerita Drew Faust at the 2018 opening of the Smith Campus Center. Jon Chase/Harvard file photoSmith graduated from the Browne & Nichols School in Cambridge in 1942. At Harvard, he lived in Lowell House. He played squash, tennis, basketball, and football, and he participated in the Navy V-12 program.After World War II, Smith went to work for General Cinema Corp., then a family-controlled drive-in theater chain. Rising to become chairman and chief executive officer, he led the company’s development into a diversified enterprise known as Harcourt General Inc., a Fortune 500 company that at various times included movie theaters, publishing houses, retail stores (including Neiman Marcus), and other lines of business.For decades, Smith was a leading figure in Boston’s nonprofit community. Along with his wife, he had a distinguished history of philanthropy and service not only to Harvard but to affiliated medical institutions, including the Dana-Farber Cancer Institute, where he was chair of the board of trustees, the Joslin Diabetes Center, and Beth Israel Hospital, where he was a trustee.His and Susan’s legacy gift to Harvard made possible the Richard A. and Susan F. Smith Campus Center, which has become an anchor for Harvard’s campus and a crossroads for the community. At its opening, President Emerita Drew Faust said the re-created center would “enable us to change how we can be together, how we can learn from one another, and how we can advance the fundamental purposes of this extraordinary institution. The Smith family’s generosity launched us onto the path of making this real. They enabled this dream, and we are incredibly grateful.” The center has won numerous awards since its opening, including the Harleston Parker Medal.Other gifts from the couple include the Smith Family Graduate Science and Engineering Fellowship, which from 2011 to 2019 has provided 175 awards to almost 150 Ph.D. students in the sciences at the Graduate School of Arts and Sciences and the John A. Paulson School of Engineering and Applied Sciences (SEAS). The Smiths also endowed graduate fellowships supporting students in the arts and in Jewish studies in the 1980s, and made other generous gifts supporting the Faculty of Arts and Sciences and SEAS, including support that enabled the launch of the Harvard Integrated Life Sciences Graduate Program.Smith was co-founder and chair emeritus of The Smith Family Foundation, whose mission is “to effect permanent positive change in the lives of individuals and families across Greater Boston, especially in economically disadvantaged communities.”Smith’s generosity and drive to serve extended deep into the Boston nonprofit world, with several prominent leadership roles for diverse organizations whose missions ranged from cancer research to the arts to education. He chaired the board of Facing History and Ourselves and served as a trustee, director, or member of organizations that included the American Academy of Arts and Sciences, Boston Symphony Orchestra, Combined Jewish Philanthropies, John F. Kennedy Library Foundation, and United Cerebral Palsy Research and Educational Foundation.Upon his departure from the Corporation in 2000, Smith spoke of what his service to Harvard meant to him, describing it as an “awesome responsibility” that “has challenged my academic capabilities and pressured me to mine my business and social service career experience in order to contribute as much as possible.”“In my opinion, Harvard is at the peak of its intellectual and financial strength, and is poised to render continuing great service to mankind.”Smith is survived by three children and their spouses, Amy Smith Berylson ’75, M.B.A. ’79, and John Berylson, M.B.A. ’79; Robert A. Smith ’81, M.B.A. ’85, and Dana Smith, Ed.M. ’92; and Debra Smith Knez; eight grandchildren; and six great-grandchildren. He was predeceased by his wife of 63 years, Susan Flax Smith, in 2016, and son James A. Smith in 1970.
Those who picture Ireland in terms of sheep and rolling green landscapes may be shocked to learn the nation is far more than just a leader in agricultural exports: it is a business hub drawing major financial, technology and pharmaceutical corporations from around the globe. In her lecture Thursday titled, “An Irish Perspective: Doing Business in a Global Economy,” Irish politician and legislator Mary Hanafin detailed Ireland’s successful integration into today’s highly interconnected global economy. Hanafin attributed Ireland’s increased global economic integration in large part to the recent decline in sectarian violence and conflict between the Northern and Southern regions of the country. She said Ireland’s transformation into a “nation at peace,” a nation emphasizing friendship and cooperation rather than strife, has helped redefine negative perceptions of the country, improving not only the lives of citizens but the health of the economy. “During those early 70s years, when you said to people, particularly people who didn’t speak English, that you were from Ireland, they would say ‘boom boom,’ and they didn’t mean an economic boom,” Hanafin said. “They meant fighting and bombs and killing.” Hanafin said taking a stroll through Dublin, the capital city, will reveal to any visitor the nation’s leading role in international business. She said Dublin has become a major center for the communications industry, attracting corporate giants such as Microsoft, Amazon and Google. Hanafin said Ireland’s educational system has played a large part in attracting foreign business and investment by fostering a highly creative, technically skilled young worker population. “It is the quality and the availability of skilled people that make Ireland attractive and special,” Hanafin said. Ireland’s membership in the European Union, as well its low corporate tax rate of 12.5 percent, also boosts its appeal among corporations seeking high rates of return on their investments, Hanafin said. She said evidence of this can been seen in the large sums of money invested in Ireland internationally. “The USA invests more dollars in Ireland than it does in Brazil, Russia, India, China and South Africa combined, and we’re only a little country of 4.5 million people,” Hanafin said. “But we’re also a country that takes our business, and our business with the world, very seriously.” Hanafin said Irish companies continue to think globally, providing everything from airport biometric screening in Japan to a communications system that currently directs roughly 50 percent of mobile phone traffic in the United States. Hanafin was most struck by the extent of this global economic integration upon visiting a children’s school in the United Arab Emirates. She said watching students use Irish software to learn the Quran was “globalization at its best.” Looking forward, Hanafin said Ireland will continue to foster cooperative economic ties with nations around the world, sharing its distinct culture and heritage while learning to appreciate the cultures of other peoples. “It is about respecting not only own our culture, but the culture of the countries with who we do business,” Hanafin said. “It’s about appreciating the importance of dialogue, and friendship, and peace as a small, neutral nation in a very troubled world.” Contact Dan Brombach at [email protected]
Sign up for our COVID-19 newsletter to stay up-to-date on the latest coronavirus news throughout New York R.E.A.C.H. Program to expand with the help of NCPD Foundation.A Nassau County police program that helps authorities identify residents with cognitive disorders in the event that they go missing will soon be expanding, officials announced Tuesday.The two-year-old program, Return Every Adult & Child Home (R.E.A.C.H.), received a financial boost from the Nassau County Police Department Foundation, a nonprofit that has partnered with the county to build a new state-of-the-art police academy.The $6,000 donation from the group will help Nassau authorities purchase 5,000 wristbands, lanyards and identification cards to assist officers in identifying individuals already registered in the program or who are interested in joining.“This [identification] kit will help further speed the identification of the missing person that has registered,” Nassau County Executive Ed Mangano said at a press conference where he was joined by police brass, leaders of the police foundation and the family of a man with a cognitive disorder who has gone missing before.The program, which launched in 2010, provides law enforcement officials with information and photos of the person suffering from any one of a number cognitive disorders, including Alzheimer’s disease, dementia and autism.Police officials said those registered in the program will have their photo and other important information released to police officers in the streets within seconds.Kathy Kammerer, whose husband, Brian, was diagnosed with early onset Alzheimer’s 10 years ago, described R.E.A.C.H as an “extra safeguard” that makes it easier for her to be away from the couple’s home when she’s at work.“It was enough dealing with the fact that he was not going to remember me, my children, and our three children, but as years went by my husband also couldn’t speak anymore,” Kammerer said. “He didn’t understand, we would call his name, he wouldn’t answer to us.”Brian went missing several years ago, she said, but he was discovered at a mall in Bay Shore by authorities who quickly obtained his information through R.E.A.C.H.“This program is amazing for me,” she added.“We believe in the significance of this program,” said Eric Blumencranz, chairman of the NCPD Foundation. “This identification items will not only help our law enforcement, but they’ll help our citizens.”The foundation’s donation comes less than two months after a former top Nassau police official was found guilty for conspiracy after he squashed a burglary investigation revolving around the son of a former foundation board member. Two other top NCPD officials charged with allegedly covering up the case are awaiting trial.“I don’t take any bad reflection from it,” Blumencranz said of the verdict. “My interpretation from it is that the district attorney looked at the foundation…and gave us a perfectly clean bill of health, that we had no wrongdoing whatsoever.”Blumencranz noted that the foundation—which has raised $4 million since it opened in 2008—struggled to raise money since the investigation but has recently rebounded.Residents interested in registering a family member in R.E.A.C.H and obtaining a wristband and identification card can do so on April 20 from 9 a.m. to noon at the Nassau County Police Academy in Massapequa Park.
On June 14, we gathered a group of more than 90 credit union leaders from across North America at Harvard University to talk about cooperative strategies for sustained competitive advantage and business model evolution. And some pretty big darn deal stuff happened.The first research output delivered through our new Centers of Excellence approach came out earlier in June, and Filene Fellow and Harvard Business School professor Dennis Campbell was there to share his insights on the connection between culture and performance, further delving into the case study of Handelsbanken. We discovered how local decision-making and distributed control can be the path to long-term success. We also heard from Wisconsin’s Verve, a Credit Union all about “the new age credit union merger,” and from Conexus Credit Union in Saskatchewan, sharing their approach to put member financial well-being at the center of their strategy. continue reading » 2SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr
1) They voluntarily chose not to make a pension election at their orientation meeting with payroll. The New York State Police and Fire Retirement System (NYSPF) require that if no election is made, they, by default, be placed in the 25-year plan. They then had up to one year, from the date of joining the retirement system, to change to the 20-year plan if they so wished.2) They did not act on correspondence from the NYSPF during this one-year option period.3) Recently, they sued the town over this pension issue and lost their case in court. These members were put in the proper pension system. Taxpayers should ask the Town Board what it will cost the town if these four are allowed the benefits of the 20-year plan vs. the 25-year plan. Members can retire with no age restrictions and they start collecting their pensions immediately after filing for retirement. Let’s hold people accountable for their own actions or lack thereof. Don’t ask the town taxpayers to foot the bill for this costly redo.Sandra BusinoAlplaus Clay was a political genius, but in sum, his compromises were an 18th Century exercise of kicking the can down the road. Brands notes the last compromise included a tougher fugitive slave law. How in the name of Dred Scott does any historian think that was a great idea?Political compromises to solve problems are essential. But I’m afraid the real legacy of Henry Clay lives on in the worst sense with our current politicians. Our national debt, unfunded public pensions and growing entitlement shortfalls are all examples of pushing problems off to future generations.David OchsePorter Corners Pelosi, Schumer not honest or respectfulAfter viewing on TV the meeting President Trump had with her majesty Pelosi and prince Schumer, all I could see was two nincompoops displaying arrogant claims on the border. A few years ago, they wanted the same things for the border that the president wanted. They know full well what is taking place on the border. They really should be honest with the president and say, “We know the wall is needed, but we dislike you so much, we will not agree on the wall.”Pelosi and Schumer should be working for all the people in this country, not just a few.And at the meeting with the president, they both showed a lack of courtesy toward the president by not facing him and not really looking at him when speaking. Arrogance personified.Shirley H. GuidarelliSchenectadyMore from The Daily Gazette:EDITORIAL: Beware of voter intimidationEDITORIAL: Thruway tax unfair to working motoristsEDITORIAL: Find a way to get family members into nursing homesGov. Andrew Cuomo’s press conference for Sunday, Oct. 18Foss: Should main downtown branch of the Schenectady County Public Library reopen? We rely on many species, such as the many pollinators. If we don’t know what happens to them if there’s a nuclear war (we don’t), maybe we shouldn’t have started the nuclear age in the first place. Nothing lasts forever. Civilization won’t, and neither will the nuclear age. What happens with our large nuclear arsenal when it’s over?Nuclear powers should try to get along to avoid a crisis. Being allies with Putin isn’t the answer, but starting up the Cold War again sounds even worse.You’re better off admiring presidents before the nuclear age (Washington through Hoover) more and admiring less those during the nuclear age. That’s how important this issue is. Americans tend to do the opposite.It’s claimed horseshoe crabs go back 450 million years. All species should attempt to be the horseshoe crab. Why do I have a feeling humans won’t come close?Colin YunickCharlton Get along to avoid a potential nuclear warVasili Arkhipov was a Soviet officer credited with preventing a Soviet nuclear strike during the Cuban Missile Crisis. He’s mostly forgotten today, but it’s believed we came close to a nuclear war. Abortion has severe long-term effectsIf you want to know what’s wrong in America, just read Don Steiner’s Jan. 17 letter and you will see how blind we have become to the murder of innocent children in this country. Hitler has nothing that even comes close to over 50 million innocent girls and boys being ripped from their mother’s womb and disposed of like yesterday’s garbage. Fifty percent of those children were most likely girls. Where’s their right to choose? The Democratic Party is so self-absorbed that this is supposed to be a positive claim to fame for them? No lasting effects? It’s easy for you to say that, Don, as you were allowed to live and have a place in this world. Meanwhile, you celebrate the death of 50 million children. There are 50 million long-lasting effects that you will have to answer for one day.Denise CrisciScotia City must realize the benefits of its treesSo let’s see, the city of Schenectady will no longer replace trees it removes. This is despite the fact ordinances require it and the fact that trees clean the air of pollution, calm aggressive drivers and can lower summer sizzling sidewalk temperatures by 10 degrees. The city can stop the tearing down of affordable housing options and instead allow construction built of flammable particleboard far out of the reach of the average person. And it will not replace city sidewalks.It’s time for city workers to move their desks out onto the summer sidewalks, where the heat can rise above 100 degrees, let their homes be demolished and replaced by new developments they can’t afford and which create more sidewalks that DPW can’t keep up with. And let’s find out if city pensions are invested, as I suspect, in construction companies that can make campaign donations and fill the city to the brim with developments that few can afford to live in and overburden the city’s Public Works Department.The people who work on your cars and stock the grocery stores for you cannot afford to live in these new developments. They are living in the inner cities, forced to ride the bus and deal with the relentless summer heat on the treeless streets. They’re very likely to develop asthma from the filthy air and from trying to make their way down the broken sidewalks as they wait for the city bus to take care of them. All the while, city officials sit in air-conditioned offices and think of new ways to tax them.Beth R. JacobsNiskayuna Categories: Letters to the Editor, OpinionTaxpayers shouldn’t pay for pension redoIn reference to The Daily Gazette’s Jan. 7 article about the town of Niskayuna’s contracts, the statement Denise McGraw made about four long-term members of the force, who were not put in the proper pension system when they started their employment, is incorrect.I worked 22 years administrating payroll and personnel practices in the Comptroller’s Office at the town of Niskayuna. These members have three facts in common: Clay’s compromises delayed solutionsI started to read Professor H.W. Brands’ recent column in The Gazette on compromise with the hope I would find something I agreed with. But while I still believe that compromise is essential in politics, I wonder if the author could have possibly chosen a worse set of examples than Henry Clay’s compromises. As Brands points out, Clay repeatedly engineered compromises between the free and slave-holding states, which worked out great, at least temporarily (for everyone but the slaves). But it was only a viable strategy as long as new states could be admitted. The fact the Pacific Ocean existed made a lot of future compromises unlikely. What didn’t get addressed was the underlying problem: slavery.
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As many as 513 Indonesian domestic workers have been repatriated from neighboring Malaysia after they were given the all-clear for COVID-19 infection.Priagung Adhi Bawono, the head of the Medan Port Health Authority (KKP), said that each Indonesian migrant worker (TKI) had been accounted for and confirmed free of infection after testing negative for the virus upon their arrival at Kualanamu International Airport in Deli Serdang regency, North Sumatra.“The preliminary results show that none of the [repatriated] domestic workers have any symptoms [of COVID-19]. They all tested negative,” Priagung told The Jakarta Post on Saturday. He added that the workers had been examined in Malaysia prior to their repatriation, but noted that some of the workers had flu-like symptoms, including dry cough and dizziness.As of Saturday, North Sumatra had recorded at least 59 confirmed cases and eight deaths.To ensure public health and safety, said Priagung, all recently repatriated migrant workers were isolated for 14 days at a special facility at Cadika Lubuk Pakam park in Deli Serdang, or at Suwondo Air Base in Medan.Whiko Irwan, the head of the North Sumatra COVID-19 task force, said that all repatriates would undergo rapid testing on the first and 10th days of their isolation periods, as well as physical exercise and psychological evaluation. Read also: COVID-19 news is not all bad. Read this to stay positive“There are 318 [TKI] quarantined at Soewondo Air Base, whereas 134 others have been isolated at Cadika Lubuk Pakam Park,” Whiko said.Soewondo Air Base Commander Col. Meka Yudanto said that the majority of repatriated workers quarantined at the air base were North Sumatra natives, while the others came from regional provinces including Java.North Sumatra Governor Edy Rahmayadi had submitted a formal request to the Home Ministry for the repatriation of North Sumatran workers from Malaysia amid the health emergency in the neighboring country, said Meka.The Malaysian government extended until April 28 its “movement control order”, which is technically a lockdown, in an effort to curb the rapid spread of the virus there, Antara News reported.By Saturday, Malaysia had recorded 4,530 confirmed cases and 70 deaths from the disease.Many of the repatriated TKI had police records in Malaysia for overstaying their visas, said Kualanamu Immigration head Tedi Hartadi Wibowo.Zakiah, a TKI from Jambi, said she entered Malaysia illegally in 2018 on a tourist visa. She found work as a waitress at a local restaurant, but was soon arrested by Malaysian immigration officers and sentenced to seven months in prison.“I’ve learned my lesson. I won’t enter Malaysia through unofficial channels ever again,” Zakiah told the Post on Thursday, when shse arrived at Kualanamu airport.She said she didn’t mind being quarantined before returning to her hometown so that her family would be safe. (rfa)Topics :