A step closer to tissue-engineered kidneys

first_img Engineered mini-kidneys come of age A glomerulus-on-a-chip could model patient-specific kidney diseases, guide therapeutic discovery Related Growing organoids under flow increases their potential for drug testing, regenerative medicinecenter_img Human stem cells model the kidney’s filtration barrier Every day our kidneys tackle the daunting task of continuously cleaning our blood to prevent waste, salt, and excess fluid from building up inside our bodies. To achieve this, the kidneys’ approximately 1 million minute filtration units, called glomeruli, first remove both waste products and precious nutrients from the bloodstream. Then, specialized structures known as the proximal tubules reabsorb the “good” molecules — glucose, amino acids, some vitamins, and electrolytes — returning them to the bloodstream.But the reabsorptive functions of the proximal tubules can be compromised by drugs, chemicals, and genetic and blood-borne diseases. Because our understanding of how these effects occur is still limited, researchers have been working to replicate proximal tubes and other kidney structures in the lab so they can better study their functions, screen drugs without testing on humans or animals, and ultimately use them as a foundation to engineer kidney replacements for diseased or damaged organs.To help study renal reabsorption, in 2016 Wyss Institute core faculty member Jennifer Lewis and her team — working within the institute’s 3D Organ Engineering Initiative, which she co-leads, and in collaboration with the Roche Innovation Center Basel in Switzerland — created a 3-D proximal tubule model in which fluids could be continuously streamed through the tubules.While that model removed molecules from the system, however, it lacked a functional blood-vessel compartment for picking up molecules again so they could be reabsorbed by the proximal tubules.This week, Lewis’ team has presented a solution to that problem: a 3-D vascularized proximal tubule model they created in which independently perfusable tubules and blood vessels are printed adjacent to each other within an engineered extracellular matrix. Their study is published in the Proceedings of the National Academy of Sciences (PNAS).“We construct these living renal devices in a few days and they can remain stable and functional for months,” said first author Neil Lin, a Roche Fellow and a postdoctoral fellow on Lewis’ team. These 3-D vascularized proximal tubules, Lin continued, demonstrate that the team’s multitissue constructs are indeed mature and functional. “[They] exhibit the desired epithelial and endothelial cell morphologies and luminal architectures, as well as the expression and correct localization of key structural and transport proteins and factors that allow the tubular and vascular compartments to communicate with each other,” he said.,As a first step toward testing drugs and modeling diseases, the team induced hyperglycemia, a high-glucose condition typical of diabetes and a known risk factor for vascular disease, into their model by circulating a fourfold-higher-than-normal glucose concentration through the proximal tubule compartment. “We found that high levels of glucose transported to endothelial cells in the vascular compartment caused cell damage,” said Kimberly Homan, a co-author of the study and a research associate in Lewis’ group at the Wyss Institute and the Harvard John A. Paulson School of Engineering and Applied Science (SEAS). “By circulating a drug through the tubule that specifically inhibits a major glucose transporter in proximal tubule epithelial cells, we prevented those harmful changes from happening to the endothelial cells in the adjacent vessels.”The team’s immediate focus is to further scale up their new model for use in pharmaceutical applications. “Our system could enable the screening of focused drug libraries for renal toxicity and thus help reduce animal experiments,” said Annie Moisan, a co-author and industry collaborator on the study, and principal scientist at Roche Innovation Center Basel. “I am thrilled by the continued efforts from us and others to increase the physiological relevance of such models, for example by incorporating patient-specific and diseased cells, since personalized efficacy and safety are the ultimate goals of predicting clinical responses to drugs.”“Our new 3-D kidney model is an exciting advance, as it more fully recapitulates the proximal tubule segments found in native kidney tissue,” said Lewis, who is also the Hansjörg Wyss Professor of Biologically Inspired Engineering at SEAS, the Jianmin Yu Professor of Arts and Sciences, and a member of the Harvard Stem Cell Institute. “Beyond its immediate applications for drug screening and disease modelling, we are also exploring whether these living devices can be used to augment kidney dialysis.” Currently, life-saving dialysis machines filter blood, but they are unable to retrieve from the filtrate the nutrients and other molecules that the body needs for many of its functions, which can cause specific deficiencies and complications down the line. Lewis and her colleagues believe that 3-D bioprinted vascularized tubules may lead to improved renal replacement therapies.“This study presents a significant step forward in human kidney engineering that enables human disease and drug-related studies to be carried out over extended periods of time in vitro,” said Wyss Institute Founding Director Donald Ingber, who is also a professor of bioengineering at SEAS and the Judah Folkman Professor of Vascular Biology at HMS and the Vascular Biology Program at Boston Children’s Hospital. “It also represents a major step forward for the Wyss Institute’s 3D Organ Engineering Initiative, which aims to generate functional organ replacements with enhanced functionalities for patients in need.”The study was also authored by present and past members of Lewis’ team Sanlin Robinson, David Kolesky, and Nathan Duarte. It was funded by grants from the National Institutes of Health, Harvard’s Wyss Institute for Biologically Inspired Engineering, a Roche Postdoctoral Fellowship, and a donation from the GETTYLAB.last_img read more

Amid darkening clouds, the best road forward

first_img The Daily Gazette Sign up for daily emails to get the latest Harvard news. The COVID-19 pandemic has slammed the brakes on the global economy, putting a number of industries — including higher education — in peril. Some colleges and universities fear for their very existence, but even those on more solid footing face tough financial choices. The Gazette spoke with Thomas J. Hollister, Harvard’s vice president for finance and chief financial officer, to learn more about the latest developments in how the coronavirus has affected the University’s finances, altered budgets in its Schools and Units, and left leadership with difficult decisions about the best way to protect the health of the community while preserving Harvard’s enduring mission.Q&AThomas J. HollisterGAZETTE: As Executive Vice President Katie Lapp wrote in a message to the community several weeks back, Harvard is facing significant financial challenges. The University’s revenue for this fiscal year is estimated to be $415 million less due to the COVID-19 pandemic, and next year, Harvard is projecting a $750 million revenue shortfall. Can you provide some more context for these figures?HOLLISTER: The COVID-19 pandemic and the corresponding economic downturn have disrupted every aspect of the University’s operations, and in turn reduced all sources of revenue. It’s important to underline that the $750 million projection for the coming fiscal year is an estimate. There are many unanswered questions that we, and our peers in higher education, just don’t know the answers to, such as how many students will enroll this coming year, when will they be back on campus, how much increased financial aid will they need, when will research resume, how will donations be affected, among many others that will affect the operating environment and University revenues. So, the $750 million estimate could end up being less than that, or unfortunately, it could be much more.GAZETTE: The state of the endowment, of course, has a lot to do with the University’s budgetary health. And as you’ve said before in this space, every penny of the annual distribution from the endowment is subscribed and utilized in support of Harvard’s mission. Can you give us a sense as to how this works?HOLLISTER: The endowment has been adversely affected by the economic downturn and the recent declines in the capital markets. As you mentioned, and contrary to the oft-voiced public opinion that the endowment is hidden away and unused, earnings from the endowment are distributed annually without fail and represent Harvard’s largest source of revenue for teaching, learning, and research.Moreover, a singular Harvard endowment does not exist; there are 13,000 individual endowments across the University, and earnings from these 13,000 endowed funds cannot be spent freely. Harvard has to honor each donor’s wishes through legally binding gift agreements that specify two inescapable fiduciary obligations: First, 70 percent of Harvard’s endowed funds must be spent on specific, donor-chosen restricted purposes, and second, 100 percent of Harvard’s endowed funds must distribute earnings annually and in perpetuity. This means that endowed funds are not savings accounts that can be all saved up for a rainy day, used for whatever is judged the most important purpose at the moment, or liquidated by choice. Think of the endowment as a collection of annuities, mostly restricted in purpose, whose annual distributions are affected by the capital markets and inexorably tied to the market value of the endowment. We cannot escape the fact that a lower market value for the endowment means less revenue for Harvard.Also, contrary to popular perception, Harvard does not have unlimited wealth. Harvard’s resources, whether measured in annual revenues or the endowment’s capacity to make distributions, are subject to the economy, capital markets, and the generosity of donors. As a reminder, during the 2008‒2009 recession, the endowment lost approximately 25 percent of its value, and distributions had to be cut approximately 20 percent.GAZETTE: What does this mean for the coming year’s endowment distribution and operating budgets for the Schools and Units?HOLLISTER: Harvard does not intend to be miserly on planned endowment distributions for the coming year, intending to distribute as much as it responsibly can. The total dollar amount will be 2 percent less than the current year, but depending upon how the stock market behaves, it is likely to be the largest in many years as a percentage of the market value of the endowment.GAZETTE: Can you talk a little about the special assessment that will come into play in the coming fiscal year?HOLLISTER:  Yes. Members of the Corporation recently voted a special assessment, which is a one-time assessment on the coming year’s distribution, with the proceeds to be used at the discretion of the deans of Harvard’s Schools to cover the unexpected and immediate costs of the pandemic, including room and board rebates and students’ moving costs, as well as expenses in the coming year to enhance the excellence of remote learning, provide increased financial aid, reopen and reconfigure labs, as well as many other steps across campus to create a protective public health environment for the community.So, although the endowment distribution across Harvard for FY21 will be 2 percent less than in FY20, the net effect is effectively 6 percent less to underlying fund beneficiaries, as the special assessment is about a 4 percent charge to begin to cover the pandemic-related costs.GAZETTE: Harvard has invested significantly in protections for its workforce in the short term, guaranteeing pay to workers who may no longer have work to do based on the move to virtual learning through June 28. But the revenue declines are massive. The University will undoubtedly need to make tough decisions as the pandemic’s economic impact grows. Already, Harvard has instituted a hiring and salary freeze, while limiting discretionary spending and freezing many of its capital projects. Lapp’s recent letter said that furloughs and layoffs may have to be considered. Can you provide some further context for how this, or other difficult decisions related to the University’s finances, might play out?HOLLISTER: An immutable and inescapable financial reality for any organization is that the outflows of money must match the inflows. Harvard’s inflows in the form of revenues have been sharply curtailed during the current pandemic, and so our outflows on spending must soon be similarly curtailed. A second financial reality is that resources are never limitless, and contrary to what some imagine, Harvard is no exception. Unfortunately, these two realities mean that we cannot do what everyone wants; choices are necessary; and more difficult decisions will need to be made.Already, we’ve seen peer institutions forced to suspend retirement contributions for their employees, as well as the announcement of furloughs and layoffs. The very existence of some colleges and universities is seriously threatened. Harvard’s Schools and Units have already instituted a host of cost-saving measures to help manage against the revenue losses we are projecting. You’ve mentioned many of those, all of which we’ve undertaken prior to considering any workforce actions, but furloughs and/or layoffs may be necessary. As Executive Vice President Lapp wrote in her letter, Harvard is committed to limiting the extent of any workforce actions.GAZETTE: Throughout all of this, University leadership has continued to reference Harvard’s core mission to teaching and scholarship. How can we continue to invest in this mission during such challenging times?HOLLISTER: I’ve previously mentioned that we extensively interviewed community members who were involved across Harvard in the ’08‒’09 recession and learned that when tough decisions had to be made, the community took solace and pride when teaching and research were placed at the top of the priority list. These core activities are at the top of the priority list now.One advantage that Harvard has, beginning with the School deans, is an extraordinary group of talented leaders across its Schools who are accustomed to making local resource decisions in the best interests of their respective missions. In this respect, Harvard’s decentralization is a real plus, as it allows for decision-making based in the specific needs of its individual Schools.On the other hand, the University is committed to One Harvard, and it’s critical in difficult times such as these to have principled leaders who share clear priorities. We’ve seen this in the University-wide leadership, from President [Larry] Bacow, Provost [Alan] Garber, and from EVP Lapp, that first and foremost, Harvard is devoted to ensuring the health and safety of its community members, and secondly, to preserving the integrity of its mission to teaching and learning. The road ahead will be difficult, but I am hopeful that Harvard will find the best path forward thanks to the leadership of our deans, and the countless contributions of faculty and staff to carry on and sustain our teaching, learning, and research activities with a continuing eye on excellence, despite the unexpected adversity.Interview was edited for clarity and condensed for space.last_img read more

Saint Mary’s enacts test optional policy

first_imgAs Saint Mary’s students settle into the first semester of the 2018-19 academic year, high school students begin the admissions process for colleges and universities around the country. Generally, applications require a transcript, essay and ACT or SAT test score. This year Saint Mary’s is adapting its application process, according to its website, to “engage all students, no matter their background.”“Saint Mary’s has been studying the issue for over 10 years,” director of admission Sarah Dvorak said. “For us, the greatest predictor of success at the College is the high school GPA combined with the strength of the coursework and not the standardized test results. In addition, there is an abundance of data out there that clearly demonstrate the tests have a much more adverse impact on women, and students from underrepresented populations and lower socioeconomic backgrounds. This is in direct conflict with our mission as a College. Now we can add that we recognize there are outstanding, academically-prepared students, who did not do well on a test on Saturday morning, but we believe they can, too, flourish at Saint Mary’s.”The College’s mission statement defines the values of students and faculty. Dvorak said they strive to make a difference in the world, regardless of their background or socioeconomic status.“There are more than 1,000 colleges and universities in the U.S., including top-tier institutions, who have chosen not to require standardized test scores for admission,” vice president of enrollment management Mona Bowe said. “I believe that elevates Saint Mary’s to being recognized as one that can break with tradition if it provides access to a superb education to talented students, who for whatever reason, did not test well. It speaks to our willingness to take a stand if it means more students can benefit from the opportunity now available to them.”First year McKenzie Looney said she would have been interested in the change to the application process as a high school senior.“I think this would have helped me because personally I am not a great test-taker,” Looney said. “I feel that standardized tests have shown that they can not properly gage someone’s actual intellect. This makes Saint Mary’s different because I think they have realized that there is more to a person than one standardized test. People can help contribute to a college without being great at answering a bunch of questions in four hours.”The admission team brought the proposal of changing the application process to the Admission and Scholarship committee. The decision was made by both the committee and council together after viewing supporting data. Now applicants who choose to not include a test score will have to have a GPA between a 3.2 and 4.0, submit an academic writing sample and attach a letter of recommendation from a high school teacher of their sophomore through senior years, according to the admission website.“Admission to Saint Mary’s is a holistic process,” Bowe said. “A process that considers a number of factors in the admission decision. When a student is denied admission to the College, the decision is not based on a single factor. The process will remain the same, and all other factors will be considered when admitting students who choose not to provide their scores.”Tags: Saint Mary’s Admissions, test optionallast_img read more

Is the credit union movement harnessing the power of cooperation?

first_img 5SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr I’ve been catching up on my reading and ran across two articles in the August 2015 issue of Scientific American that touched on the concept of cooperation. Of course, cooperation is at the heart of the credit union movement — people joining together to help each other. Cooperation extends far beyond the individual credit union — credit unions join together in many different ways to help each other advance. This has enabled credit unions to compete and prosper in an intensely competitive marketplace that many predicted would see the end of credit unions.The first article I read was “The Most Invasive Species of All.” It asked the question of how homo sapiens was able to expand out of Africa to all regions of the worlds. Was it bigger brains? Better weapons? Sheer luck? The answer of anthropologist Chris W. Marean is “a genetically encoded penchant for cooperation with unrelated individuals.”“The joining of this unique proclivity to our ancestors’ advanced cognitive abilities enabled them to uniquely adapt to new environments,” Marean writes. “It also fostered innovation, giving rise to a game-changing technology: advanced projectile weapons. Thus equipped, our ancestors set forth out of Africa, ready to bend the whole world to their will.”The second article in the same issue that caught my attention was “Planet Hard Drive,” a discussion of information theory as it applies to people. The author, César A. Hidalgo, sees each of us as an organic, information-generating computer, transforming ideas into useful products or activities. The problem, Hidalgo says, is that each of us is limited. To transcend our own limitations, we need to form social and professional networks. This generates ever richer stores of information that lead to economic and social progress. He envisions ever faster progress ahead as technology and trade break down barriers of language, culture, and nationality and bring people of the world into closer collaboration. continue reading »last_img read more

Development

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Oxfordshire industrial

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[UPDATED] Death of isolation patient ‘not COVID-19’, says Indonesian hospital

first_imgA male patient suspected of COVID-19 died on Feb. 23 at Kariadi Central General Hospital in Semarang, Central Java, after being treated in an isolation room for nearly a week.The patient had reportedly returned to Indonesia on Feb. 12 from Spain via Dubai, the United Arab Emirates (UAE), and presented symptoms of the disease after his arrival, including fever, cough and shortness of breath. He was admitted to the hospital on Feb. 17 and transferred to an isolation room two days later. Kariadi hospital’s medical and nursing director, Agoes Oerip Poerwoko, confirmed that the patient died on Sunday, but asserted that SARS-CoV-2 – the virus that causes COVID-19 – was not the cause of the patient’s death.  Editor’s Note: This article has been updated to include the hospital’s explanation for the patient’s cause of death. “The patient died not from the coronavirus, but due to severe breathing difficulties. The result of a laboratory test from the Health Ministry’s research and development center came out a day after the patient was buried, and it showed he tested negative for the coronavirus,” Agoes said as quoted by kompas.com on Tuesday. Most recently on Wednesday, Agoes said that the patient had died of bronchopneumonia and reiterated that he had tested negative for COVID-19.“The patient tested negative for the coronavirus according to the observation of the Health Research and Development Agency [Balitbangkes] in Jakarta. Balitbangkes did the test,” he said.Agoes said that the patient’s body was wrapped in plastic and then cremated, which was “normal procedure in infectious disease management”. Fathur Nurcholis, a doctor who had treated the patient, said the patient had difficulty breathing and eventually succumbed to multiple organ failure.Besides the recently deceased patient, Agoes said that the hospital had also treated two other patients suspected of COVID-19 infection, an Indonesian and a Japanese who had traveled to other countries. The two patients had been discharged after testing negative for SARS-CoV-2.Kariadi hospital has treated at least 23 patients for suspected coronavirus infection since January. Four of the patients were nationals of China, Japan, and South Korea, all of which have localized outbreaks. The city of Wuhan in Hubei province, China, is the epicenter of the COVID-19 outbreak that emerged in December 2019, which has affected 41 countries to date.Read also: ’It is not COVID-19’: Indonesian health official mixes up disease and virus“Of the 23 patients, 10 of them are patients under surveillance because [they] show clinical symptoms [of COVID-19], while the 13 others are under observation and have been allowed to go home,” said Agoes.Separately, Kariadi hospital medical services head Nurdopo Baskoro said the hospital had just admitted a female patient on Monday who was being treated in an isolation room.”[The patient] is a 25-year-old woman who came to the hospital in the afternoon complaining about having a fever, coughing and chills. She has been in close contact with foreigners from [South] Korea and China, but has no history of traveling abroad,” Nurdopo said.As of Feb. 25, more than 80,400 people around the world have contracted the virus and more than 2,700 deaths have been linked to COVID-19. Indonesia has reported zero confirmed cases to date, although at least nine Indonesian crewmen aboard the Diamond Princess cruise ship in Japan have tested positive for COVID-19. In addition, a Chinese national and a Japanese national were diagnosed with the disease upon their return from vacationing in Bali over the past two months, according to reports issued by the infectious disease centers in those countries. (syk) Topics :last_img read more

El Gobernador Wolf anuncia un programa de subvenciones de $225 millones para pequeñas empresas afectadas por la COVID-19

first_img SHARE Email Facebook Twitter Economy,  Español,  Press Release El Gobernador Tom Wolf hoy anunció un programa de subvenciones de alcance estatal de $225 millones para apoyar a las pequeñas empresas que se vieron afectadas por la crisis de salud pública producida por la COVID-19 y la posterior orden de cierre de empresas.“A medida que atravesamos la pandemia de COVID-19 y nos centramos en la reapertura de nuestro estado, debemos ayudar a todos los residentes de Pennsylvania a recuperarse. Necesitamos brindar asistencia a aquellos que se vieron perjudicados por la pandemia y la recesión económica resultante”, dijo el Gobernador Wolf. “Este nuevo programa brindará apoyo directo a las empresas perjudicadas para cubrir los gastos operativos durante el cierre y la transición a la reapertura”.La financiación se desarrolló en colaboración con los legisladores estatales y se asignó a través del presupuesto estatal recientemente promulgado, que incluyó $2.6 mil millones en fondos de estímulo federal a través de la Ley federal de Ayuda, Alivio y Seguridad Económica por el Coronavirus (Ley CARES), de los cuales $225 millones se destinaron como medidas de alivio para pequeñas empresas.El Departamento de Desarrollo Comunitario y Económico (DCED, por sus siglas en inglés) distribuirá los fondos a las Instituciones Financieras de Desarrollo Comunitario (CDFI, por sus siglas en inglés), que luego administrarán los fondos en forma de subvenciones.Las empresas elegibles podrán usar las subvenciones para cubrir los gastos operativos durante el cierre y la transición a la reapertura, y para recibir asistencia técnica, que incluye la capacitación y la orientación de los propietarios de empresas a medida que se estabilizan y reabren sus negocios.Los fondos estarán disponibles mediante tres programas:$100 millones para el Programa de revitalización de empresas de la calle principal (Main Street Business Revitalization Program) para pequeñas empresas que sufrieron pérdidas producto de la orden del gobernador del 19 de marzo de 2020 relacionada con el cierre de todas las empresas que no son de soporte vital y que tienen o tendrán gastos para adaptarse a nuevas operaciones comerciales relacionadas con la COVID-19;$100 millones para el Programa de revitalización de empresas históricamente desfavorecidas (Historically Disadvantaged Business Revitalization Program) para pequeñas empresas que sufrieron pérdidas producto de la orden de cierre de empresas, que tienen o tendrán gastos para adaptarse a las nuevas operaciones comerciales relacionadas con la COVID-19, y en las que las personas con desventajas sociales y económicas poseen al menos un 51% de interés y también controlan la gestión y las operaciones comerciales diarias.$25 millones para el Programa de aplazamiento de pago de préstamos y reserva de pérdidas (Loan Payment Deferment and Loss Reserve Program), que dará a las Instituciones Financieras de Desarrollo Comunitario (CDFI) la oportunidad de ofrecer tolerancia y alivio respecto de los pagos a las empresas de cartera existentes que están luchando debido a las repercusiones de la COVID, así como fortalecer la posición financiera de las CDFI que están sufriendo un aumento significativo de los incumplimientos en sus carteras de préstamos existentes.“Quiero agradecer al Gobernador Wolf por comprometer su liderazgo en la Asamblea General para informar el proceso de trasladar la ayuda federal a los más perjudicados por la pandemia de COVID-19. También quiero agradecer al liderazgo del bloque demócrata del Senado que colaboró con nuestros miembros para formular un plan estratégico para el despliegue de casi $4 mil millones en asistencia federal”, dijo el Senador estatal John Blake (demócrata por Lackawanna). “El Programa de revitalización de empresas de la calle principal es un reflejo de esa cooperación y liderazgo y se reunirá con los propietarios de pequeñas empresas de Pennsylvania allí donde se encuentran, en la calle principal, luego de casi tres meses de ventas a pérdida o sin ventas. Permitirá que los propietarios de pequeñas empresas en todo el Estado cumplan con los pagos de sus seguros, alquileres, primas de seguros médicos, impuestos locales y otros gastos que de otro modo no podrían cubrir debido a la pérdida de ventas. Finalmente, quiero agradecer a las 17 CDFI de todo el estado, igual que al DCED, por su profesionalismo, agilidad, urgencia y dedicación para llevar esta financiación federal a las pequeñas empresas que más lo necesitan lo más rápido posible”.“Los Programas de revitalización de empresas de la calle principal y de empresas históricamente desfavorecidas brindarán medidas de alivio bienvenidas a las empresas familiares en los vecindarios de todo el estado. Desde que comenzó esta pandemia, hemos escuchado las necesidades de los talleres de carrocería de automóviles, las peluquerías, las esteticistas, los dueños de pizzerías, los establecimientos de soul food y otras empresas en nuestras comunidades. Las necesidades de estas empresas que no pudieron obtener la ayuda que tanto necesitaban de otros programas estatales y federales fueron una prioridad en el anuncio del Programa PA CARES el 29 de abril en nuestro bloque Demócrata del Senado, dijo el senador estatal Vincent Hughes (D-Philadelphia/Montgomery). “Durante meses, mi oficina ha trabajado con una red de organizaciones comunitarias confiables que tienen una trayectoria comprobada de trabajo con nuestras pequeñas empresas, las CDFI, para encontrar una solución para prestar asistencia a las empresas de nuestro vecindario. Creo que estos programas son esa solución. Todavía hay más trabajo por hacer, pero estos programas son una victoria para Pennsylvania y sus pequeñas empresas”.“Las pequeñas empresas se llevaron la peor parte de las repercusiones económicas de la pandemia. Esta inversión es un buen primer paso hacia su recuperación y la recuperación de las comunidades en todo el estado”, dijo el líder demócrata de la Cámara de Representantes, Frank Dermody. “Este programa beneficiará a múltiples industrias diversas, propuesto por muchos miembros en la legislatura, incluidos los diputados Jared Solomon, Morgan Cephas, Jake Wheatley, Ryan Bizzarro, Chris Sappey y Melissa Shusterman”.La PA CDFI Network es un grupo de 17 instituciones financieras de desarrollo comunitario con sede en Pennsylvania que principalmente brindan opciones de financiamiento a pequeñas empresas.“Nos complace trabajar con el Gobernador en el Programa de asistencia estatal a las pequeñas empresas a causa de la COVID-19 (COVID-19 Relief Statewide Small Business Assistance) para brindar oportunidades económicas a los afectados por la pandemia de COVID-19”, dijo James Burnett, vicepresidente de la PA CDFI Network. “Sabemos lo importante que es respaldar a las empresas más pequeñas y vulnerables en todo el estado, incluidas las empresas históricamente desfavorecidas y de la calle principal”.Hay más información disponible en el sitio web de DCED.View this information in English. June 08, 2020center_img El Gobernador Wolf anuncia un programa de subvenciones de $225 millones para pequeñas empresas afectadas por la COVID-19last_img read more

2020 Olympics: Sports Minister plans with Presidents of Federations on Nigeria’s successful…

first_imgMinister of Youth and Sports Development Mr. Sunday Dare met with the Ministerial Advisory Committee and Presidents Federations of Sports who will represent Nigeria at the Tokyo 2020 Olympics games. The Minister then took briefs from the Secretary of the Ministerial Advisory Committee, the Nigeria Olympic Committee (NOC), and the Paralympic Committee of Nigeria. Lists of athletes who have qualified for the competition and those that are yet to qualify were made known, including the mandatory sports for qualification to the international event. Other items that were deliberated upon are; the budget allocation and accreditation processes for the games. The Minister also briefed the attendees on the stages of mobilization of funds and sponsorship for the event. Read Also:Sports Minister clears doubts on Edo 2020 National Sports Festival It would be recalled that at the last Olympics, only one bronze medal was recorded in football and none from athletes. This the Minister said has necessitated a timely meeting of Federations and continuous feedbacks to put plans in place for a better outing at the Tokyo Olympics. FacebookTwitterWhatsAppEmail分享 The meeting which was held at the Media centre of the National Stadium in Abuja, was aimed at preventing a repeat of the last two outings international outings among which was the London Olympics in which no medal was recorded. Setting the agenda for the meeting, the Minister stressed the need for the Ministry and the Federations to maintain common ground in order for Nigerian athletes to give Nigeria a worthy representation at the Olympics games. “It is important we meet and have a time frame. We need to be on the same page to prepare for the Olympics. We are going to create a feedback system beyond this meeting and we going to have a similar meeting down the road, yes to ensure to the smooth running of Olympics.”Advertisement Loading… Promoted Content6 Extreme Facts About Hurricanes5 Of The World’s Most Unique Theme Parks7 Facts About Black Holes That Will Blow Your MindThe Very Last Bitcoin Will Be Mined Around 2140. Read MoreWhat Is A Black Hole And Is It Dangerous For Us All?Portuguese Street Artist Creates Hyper-Realistic 3D Graffiti7 Truly Incredible Facts About Black HolesBut Who In The World Taught Them Those Moves? Was It Papa Bear?Birds Enjoy Living In A Gallery Space Created For ThemCouples Who Celebrated Their Union In A Unique, Unforgettable Way7 Train Stations In The World You Wish To Stay At Longer14 Hilarious Comics Made By Women You Need To Follow Right Nowlast_img read more

Pacer’s New Coach

first_imgNate McMillan is the new coach of the Indiana Pacers.  Nate was an assistant with the Pacers the last couple of years.  McMillan started out his career at North Carolina State playing under Jim Valvano.  He was drafted by the Seattle Sonics and played for them 12 years and then remained in their system until he moved on to the Portland Trailblazers before coming to Indianapolis.It will be interesting to see how he gets along as the head coach under Larry Bird.  I feel you need two traits to succeed with the Pacers.  You must have complete conviction in your system and win with it.  The other trait is to get along with Larry Bird who does not want the day-to-day job of coaching, but still keeps his thumb on what is going on.We wish Nate McMillan the best in his new position.  Just win and you will be fine.last_img read more

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